We are going through some challenges as Coronavirus spreads all over the world.It makes sense for us to be braced and have knowledge on best approaches to help our body fight the virus, in case it will be needed. We put together several informations and research content about supplements that can help fighting virus infections for you.
lobal epidemics with high morbidity and mortality is lead by Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2) at the moment.Currently there are no drugs targeting these deseases effectively.
Repurposing drugs, turns out as an effective drug discovery strategy from drugs already existing. It could shorten the time leading to a result and decrease the cost compared to novo drug discovery.
In the study linked to this article an integrative, antiviral drug repurposing methodology is shown. It is implementing pharmacology-based network medicine platform. Also it is quantifying the interplay between a HCoV–host interactome and drug targets in the human protein–protein interaction network.
Using network proximity analyses of drug targets and HCoV–host interactions in the human interactome, we prioritize 16 potential anti-HCoV repurposable drugs (e.g., melatonin, mercaptopurine, and sirolimus) that are further validated by enrichment analyses of drug-gene signatures and HCoV-induced transcriptomics data in human cell lines. We further identify three potential drug combinations (e.g., sirolimus plus dactinomycin, mercaptopurine plus melatonin, and toremifene plus emodin) captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the HCoV–host subnetwork, but target separate neighborhoods in the human interactome network. In summary, this study offers powerful network-based methodologies for rapid identification of candidate repurposable drugs and potential drug combinations targeting 2019-nCoV/SARS-CoV-2.
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